Frusciante was born in New York City on March 5, 1970, into a family of musicians. His father, John, is a Julliard-trained piano player.
His mother, Gail, is a talented violinist who is now a stay-at-home mother. His father worked as well, and the family relocated to Tucson, Arizona, and subsequently to Florida, where his father became a judge.
Frusciante traveled to Santa Monica, California, with his mother after his parents divorced.
When his mother remarried, his family relocated from Los Angeles to Los Angeles, and Frusciante engaged in the punk music community. He continuously listened to The Germs' music.
Frusciante had also started listening to the Red Hot Chili Peppers in 1984 after his guitar instructor had auditioned to be their guitarist.
John Frusciante became friends with the former drummer of Dead Kennedys, D.H. Peligro, in 1988.
They often played music together, and Peligro sometimes invited his friend Flea, the Red Hot Chili Peppers bassist. The three developed great musical chemistry.
The Slovak guitarist for the Chili Peppers died from a drug overdose in 1988. Shortly afterward, drummer Jack Irons decided to leave the group.
The leftover group members of the group hired Peligro to play drums and DeWayne McKnight to play guitar. However, McKnight did not fit with the band, and Flea recommended trying out Frusciante.
Frusciante was given the responsibility of guitarist after his audition pleased the team.
The newly reunited Chili Peppers started recording a debut album at an old mansion in the Hollywood Hills, where the band members isolated themselves for the length of the production.
The album was produced in 1991 and reached its peak at No. 3 on the Billboard 200, considerably better than their previous projects. The album's surprising popularity boosted the band to pop star status.
Frusciante was uncomfortable with this fame and success and had problems interacting with the band's success. Ultimately, he chose to quit the band in 1992.
Frusciante is considered one of the best guitarists of all time and made the "Rolling Stone" list of "100 Greatest Artists of All Time," coming in at the eighteenth spot.
He has released 12 solo albums from 1994 to 2020, in addition to the albums he has released with the Red Hot Chili Peppers and collaborations with other musicians.